Preheat the oven to 400°F.
Into a large mixing bowl, add 1/4 cup all-purpose flour and 1 teaspoon each of onion powder, garlic powder, and paprika. Whisk together.
Add 1/4 cup buffalo sauce and 1/4 cup water. Whisk to form a batter. (If using an alternative flour, you may need to add more water depending on its absorbency.)
Toss the cubed, pressed tofu in the batter to coat.
Pour 1 cup Panko breadcrumbs into a bowl. Toss the battered tofu pieces in the breadcrumbs, working a few at a time, then transfer to a baking sheet.